Bayer 205
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Bayer 205 (Germanin) is a white, odorless, and tasteless powder composed of urea and aromatic derivatives. It is used to treat trypanosomal tropical diseases, including sleeping sickness, kala-azar, and trypanosomiasis in horses and camels.
Encyclopedia entry (1928–1936)
BAIER 205 (Bayer 205, Germanin) represents a combination of urea with derivatives of the aromatic series (according to Fournier, this is the sodium salt of urea-di-p-aminobenzoyl-le-amino-m-benzoyl-1-naphthylamino-4,6,8-trisulfonic acid). A white powder, odorless, almost tasteless, easily soluble in water. It is applied for the treatment of trypanosomal tropical diseases (sleeping sickness, kala-azar of humans, trypanosomiasis of horses, camels, etc.). Dose: intravenously, intramuscularly, or subcutaneously in a 10% solution, 0.2–0.5 to 3.0 daily, for a week. After the introduction of this drug, it circulates in the blood for a long time, which is especially valuable for the prevention of trypanosomiasis. Side effects include albuminuria.
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“Bayer 205.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/bayer-205/