Chemovaccinotherapy

Chemovaccinotherapy is a direction in the doctrine of vaccinotherapy that proposes combining bacterial vaccines with chemotherapeutic substances. According to this doctrine, the mechanism of any therapeutic vaccinotherapy lies in 'inducing a focal reaction by directing the injected vaccine to the bacterial focus.' The direction of the vaccine causes a specific leukocytic reaction. If the vaccine is combined with some colloidal indicator, for example colloidal iron, then, by investigating the exudate surrounding the bacterial focus, one can prove by chemical means, for example by the reaction for Berlin blue, the presence of a significant amount of iron in the exudate, obviously due to the direction of the vaccine here with bound iron. From these experiments arises the idea of combining vaccines with chemotherapeutic substances, on the assumption that the vaccine will deliver chemotherapeutic agents to the focus. Most clearly this idea is realized in the urea gonococcal vaccine (so-called Brooke vaccine), further in the meningococcal optochin vaccine; to this also belong sulfavaccines, iatrenewaccines, iodovaccines, etc. The doctrine of chemovaccinotherapy was created and developed by Professor Belonosky and his school. Iv