HISTOZYME
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Histozyme is an enzyme that breaks down hippuric acid into benzoic acid and glycine. Found primarily in kidneys and to a lesser extent in liver, muscles, and other organs, as well as in the fungus Aspergillus oryzae.
Encyclopedia entry (1928–1936)
HISTOZYME, or hippuricase, an enzyme that breaks down hippuric acid (see) into benzoic acid and glycine. H. is found in the kidneys, where it was first discovered by Schmiedeberg, in smaller amounts in the liver, muscles, and other organs, as well as in the fungus Aspergillus oryzae. In addition to hippuric acid, H. also breaks down other acylated amino acids: phenaceturic acid, benzoyl-alanine, as well as glycocholic acid (Smodrintsev). It is assumed that the formation of hippuric acid in the kidney occurs with the participation of H., which in this case acts as a synthesizing enzyme.
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“HISTOZYME.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/histozyme/