Saligenin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Saligenin is a white, light powder with a melting point of 84-86°C, easily soluble in hot water, alcohol, and ether. It is formed from the glycoside salicin through cleavage by emulsin or saliva, and can also be obtained by the action of nascent hydrogen on salicylaldehyde or by treating an alkaline solution of phenol with formaldehyde. As a salicylate preparation, Saligenin did not gain widespread use, but in recent years, American surgeons have proposed it for local infiltrative and surface anesthesia in 2%, 4%, and 12% solutions. The drug is currently being studied in the USSR.
Encyclopedia entry (1928–1936)
Saligenin, salicyl, or ortho-oxybenzyl alcohol, diatethin, dizalgin, C6H4ONCH2OH; a white, light powder, with a melting point of 84-86°, easily soluble in hot water, in alcohol and ether. It is formed from the glycoside salicin by cleavage under the influence of emulsin or saliva; it can also be obtained by the action of hydrogen in statu nascendi on salicylaldehyde or by treating an alkaline solution of phenol with formaldehyde. As a salicylate preparation, S. did not gain widespread use. In recent years, it has been proposed by American surgeons for local infiltrative and surface anesthesia in the form of 2%, 4%, and 12% solutions. The drug is currently being studied in the USSR.
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“Saligenin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/saligenin/