Sozojodol

SOZOJODOL, as well as sozojodol preparations—salts of sozojodol (diiodoparaphenolsulfonic) acid—are not included in the 7th edition of the Russian Pharmacopoeia. Sozojodol acid is obtained from phenol by sulfonation with sulfuric acid and subsequent iodination using chloroiodine or the action of iodine at the moment of liberation. Sozojodol acid and its salts were proposed in 1888. Sozojodol acid was created with the expectation of enhancing the antiseptic action of the phenolic hydroxyl due to the introduction of iodine into the ring and decreasing the toxicity of phenol under the influence of the sulfo group, but these expectations were not fully justified. Only sozojodol acid itself possesses noticeable antiseptic action (which is characteristic of all acids of medium strength) and those of its salts in which this action is due to the properties of the corresponding cation: such are, for example, the mercury and zinc salts. Sozojodol preparations do not split off iodine in the organism. The antiseptic action of sodium and potassium salts is doubtful. Nevertheless, sozojodol preparations are still proposed in dermatological, laryngological, and venereological practice. Preparations. Sozojodol acid, Acidum sozojodolicum (dijodparaphenolsulfonicum), colorless needle-like crystals, easily soluble in water, alcohol, or glycerin; used in 2-3% solutions.-Sozojodol-sodium salt, Natrium sozojodolicum, soluble in water (1:12) colorless tiny needles; recommended as an antiseptic agent in a 2-3% solution in laryngological practice.-Sozojodol-potassium salt, Kalium sozojodolicum, a white fine-crystalline powder, sparingly soluble in water (about 2%); in view of its low solubility, it is proposed for dusting powders and the like.-Sozojodol-zinc salt, Zincum sozojodolicum, colorless prismatic crystals or crystalline powder, soluble in 25 parts of water and 2 parts of alcohol with an acid reaction; used like other similar zinc salts.-Sozojodol-mercury salt, Hydrargyrum sozojodolicum, a fine yellow-orange powder, almost insoluble in water and alcohol, easily soluble in sodium chloride solutions. Contains 32% Hg. Used as an antiparasitic and antiluetic agent, as well as in ointments and dusting powders for leg ulcers and skin diseases (especially favus). Subcutaneously in potassium iodide solution (e.g., Hydr. Sozojod. 8.0, 16% KI solution 100) in doses of 0.05-0.08. Maximum doses: daily 0.15, single 0.05. Storage as a poison (List "A"), in a tightly stoppered dark glass bottle. There are other salts of sozojodol acid that present no advantages over those listed. - The identification of sozojodol preparations comes down to detecting the corresponding

substance under suitable conditions.