Amygdalin

Pharmacology, Toxicology, Biochemistry

Also known as: Laetrile, Vitamin B17, Mandelonitrile beta-D-glucoside

Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.

Summary

Amygdalin is a glucoside found in bitter almonds and peach pits, containing about 2.5-3.5% of the substance. It is a crystalline powder, odorless and bitter-tasting, that breaks down into sugar, benzaldehyde, and hydrocyanic acid when boiled with weak hydrochloric acid or treated with the enzyme emulsin.

Encyclopedia article (1928–1936)

AMYGDALIN, Amygdalinum, C20H27NO11, a glucoside found in bitter almonds and peach pits in an amount of about 2.5-3.5%; a considerable amount of A. is contained in the leaves of the laurel cherry tree, bird cherry (Prunus padus) and bird cherry (Prunus avium) and in smaller amounts in the pits of plums, cherries and apple seeds. A. is a crystalline powder, odorless, bitter-tasting, soluble in water and alcohol, insoluble in ether, levorotatory, of neutral reaction. When boiled with weak HCl or treated with the enzyme emulsin, found in bitter and sweet almonds, A. breaks down into sugar, benzaldehyde and hydrocyanic acid. A. as such is little toxic and partly passes into the urine unchanged, but when decomposing in the intestine under the influence of enzymes and bacteria it is a source of hydrocyanic acid and can cause poisoning. A. is administered internally up to 0.02 pro dosi, as an analgesic for intestinal catarrhs in an emulsion, where A. decomposes with the formation of hydrocyanic acid.

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Cite this page

“Amygdalin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/amygdalin/