Acetophenone
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Acetophenone, also known as hypnone, is a methyl-phenyl ketone used in medicine as a hypnotic drug, though it is now rarely prescribed. The 1930s encyclopedia entry details its chemical properties, melting and boiling points, and historical administration in capsules or emulsions.
Encyclopedia entry (1928–1936)
ACETOPHENONE, hypnone, C6H5·CO·CH3, methyl-phenyl ketone, insoluble in water, but readily soluble in alcohol and ether; from alcohol acetophenone crystallizes in the form of large tablets melting at 20.5°; boiling point 200–202°. In medicine, it is used as a hypnotic (sleep-inducing agent), in some cases preferred to paraldehyde and chloral hydrate. It is prescribed (now very rarely) in doses of 0.05–0.2 in a mixture with a small amount of glycerin or fat in capsules, sometimes in an emulsion.
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“Acetophenone.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/acetophenone/