Choleval
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Choleval is a colloidal silver preparation stabilized with sodium cholate, used in the 1930s for the treatment of gonorrhea. Due to the emulsifying properties of sodium cholate, it penetrates tissues more deeply than collargol, though it is unsuitable for parenteral use or large wound surfaces due to its hemolytic and toxic effects.
Encyclopedia entry (1928–1936)
CHOLEVAL, colloidal silver with sodium cholate as a protective colloid, containing 10% Ag. Dark brown, shiny, odorless flakes, readily soluble (colloidally) in water. It is used in gonorrhea in 0.25–2.5% solutions and in the form of bougies. Its action is similar to collargol, but thanks to the emulsifying capacity of sodium cholate, Choleval penetrates deeper into tissues. Choleval is unsuitable for parenteral administration and for use on large wound surfaces due to the hemolytic and consequently toxic action of sodium cholate.
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“Choleval.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/choleval/