Globin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Globin is a protein with strongly basic properties, classified as a histone. It constitutes the colorless protein component of hemoglobin, which in this pigment is combined with the colored iron-containing part, heme. Globin can be obtained by splitting hemoglobin with dilute HCl and extracting the heme with ether in the presence of a small amount of alcohol.
Encyclopedia entry (1928–1936)
GLOBIN, a protein with sharply expressed basic properties, classified as a histone (see). G. constitutes the colorless protein component of Hb, which in this pigment is combined with the colored iron-containing part—heme. G. is obtained by splitting Hb with dilute HCl and extracting the heme with ether in the presence of a small amount of alcohol. The G. remaining in the aqueous-alcoholic solution can be precipitated by careful addition of ammonia. About 30% of the total N in G. is accounted for by N of diamino acids—arginine, lysine, and especially histidine, which determines its basic character. G. possesses antigenic properties, significantly more pronounced than those of Hb. Under certain conditions, it is possible to recombine G. with the iron-containing part of Hb, in which case methemoglobin is first obtained, which can then be converted to Hb and oxyhemoglobin.
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“Globin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/globin/