Globulinuria
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Globulinuria refers to the high content of globulin fraction in urine during albuminuria, occurring in acute hemorrhagic and severe nephritis, lipoid nephrosis, and amyloid kidney disease. Hoffman proposed using the 'protein coefficient' (the ratio of albumin to globulin in urinary protein) for prognostic purposes.
Encyclopedia entry (1928–1936)
GLOBULINURIA, high content of globulin fraction in urine during albuminuria (see); observed in acute hemorrhagic, severe nephritis, in lipoid nephrosis, and amyloid kidney disease. Chronic nephritis usually proceeds with small amounts of globulin in urine. Hoffman proposed using the determination of the 'protein coefficient' (the ratio of albumin fraction to globulin fraction in urinary protein) for prognostic purposes. An increase in the coefficient signifies improvement, while its decrease is a sign of worsening, exacerbation of the disease. According to Hoffman, in favorable cases the coefficient is always above 4.5-5; in severe nephritis the ratio falls to 1.08. The methodology for determining the protein coefficient is complex, and the regularity of these relationships is disputed by a number of authors.
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“Globulinuria.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/globulinuria/