Antitrypsin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Antitrypsin is a substance that inhibits the action of trypsin. The antitrypsin found in blood serum is of greatest practical interest, as it sharply reduces trypsin's enzymatic action when added to it.
Encyclopedia entry (1928–1936)
Antitrypsin, a substance that inhibits the action of trypsin. The greatest practical interest is in the A. found in blood serum; when added to trypsin, serum sharply reduces its enzymatic action. The antitryptic properties of serum are used for diagnosis, particularly of malignant tumors; however, a regular connection between the disease and the content of A. in serum could not be established. The nature of A. has not yet been clarified. A. is thermolabile and belongs to colloids. Some authors associate it with serum albumin, others with lipoids, in particular with unsaturated fatty acids. (Definition of A.-see Gross-Fuld method).
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“Antitrypsin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/antitrypsin/