Bence Jones Protein Body
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
The Bence Jones protein body, first identified by Bence Jones, is a rare protein that appears in urine and forms a precipitate when heated to 40-60°C, which redissolves at higher temperatures. Its presence in urine is associated with pathological changes in bone marrow.
Encyclopedia entry (1928–1936)
BENCE JONES PROTEIN BODY (Bence-Jones), a protein first identified by Bence Jones, which in very rare cases appears in urine and gives it the property of forming a precipitate when heated to 40-60°C, which dissolves at a higher temperature, coloring the liquid, and which is again precipitated upon cooling. Its appearance in urine is associated with pathological changes in the bone marrow. In its properties, the Bence J. protein body in many ways resembles albumoses, but is classified as a true protein. HNO3 on cold gives a precipitate, sometimes soluble in excess of the reagent, and upon heating dissolves almost completely. Tannin, pyrrolidine acid, metal salts, acetic acid + yellow blood salt give precipitates with the Bence J. protein body. All color reactions for protein are positive.
Related articles
Mentioned in
Cite this page
“Bence Jones Protein Body.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/bence-jones-protein-body/