Novirudin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Novirudin is a melanin-based compound that prevents blood clotting, similar to hirudin. It was used experimentally to prevent serum anaphylaxis and blood coagulation, though it discolors plasma and is less effective than hirudin.
Encyclopedia entry (1928–1936)
Novirudin, Novirudin, a preparation of melanin acid, possessing similar to hirudin (see) the property of preventing blood coagulation. Upon introduction of 0.0005 N. per 1 cm3 of blood, the blood does not coagulate for several hours. Upon addition of N. to blood in vitro, it is possible to completely prevent its coagulation. A disadvantage of N. is the sharp change in the color of plasma upon its addition (from light yellow to dark brown). Subcutaneous administration of N. proved ineffective, whereas intravenous application gave a positive result. -N. protects the animal from serum anaphylaxis. N. acts weaker than hirudin. In view of the difficulty of obtaining hirudin, N. is widely used in laboratory and experimental practice.
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“Novirudin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/novirudin/