Syntonin

SYNTONIN, an acid albuminate, obtained by infusing myosin (one of the muscle globulins) with diluted (0.1%) HCl. It is soluble (like other acid albuminates) in diluted acids and alkalis, but insoluble in water; it is precipitated from acidic and alkaline solutions upon neutralization (the reaction is reversible); it is easily precipitated from acidic solutions by adding neutral salts; coagulation upon boiling occurs only in the presence of an excess of neutral salt. Method of preparation: minced meat is washed with water and infused for 24 hours with a 10% solution of NH₄Cl. The filtered myosin solution is precipitated by an excess of water, the precipitate is again dissolved in ammonium chloride, and precipitation with water is repeated once more; finally, the precipitate is washed with water, alcohol, and ether. Upon further infusion of myosin with 0.1% HCl, myosin is converted into syntonin.