Pepsin Glycerin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Pepsin Glycerin is a patented solution containing 2-5% pepsin in glycerin with hydrochloric acid, sterosin, and novocaine with adrenaline. Developed by Pair, it was used to treat scar tissue through injections and applications, though its effectiveness was limited by frequent recurrences.
Encyclopedia entry (1928–1936)
Pepsin Glycerin, a 2-5% solution of pepsin in glycerin with the addition of 1-2% HCl, 1% sterosin (sterile pepsin in normal saline) and 12% novocaine with adrenaline. A patented preparation made according to the instructions of Pair (Raug), it is called pepsinat (a 1-2% solution of which is used). It is used in scar processes (adhesions, scars, contractures, etc.). Pair, who initiated this method of treating scar processes, explains the favorable effect of P. p. on them mainly by the enzymatic action of pepsin, which dissolves fibrin. Particularly favorable results from the use of P. p. in peritoneal adhesions were seen by Pair, Oshman and others. P. p. is used in the form of injections, applications. The method did not receive wide distribution, as further observations showed that in most cases recurrences of scar processes occurred.
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Cite this page
“Pepsin Glycerin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/pepsin-glycerin/