Skin Amyloidosis
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
This article describes a rare condition of the skin characterized by the deposition of amyloid substance, presenting as isolated nodules and often accompanied by itching. It notes that the disease is localized to the skin and does not involve the internal organs.
Encyclopedia entry (1928–1936)
SKIN AMYLOIDOSIS, amyloidosis cutis, partial impregnation of the skin with amyloid substance. An extremely rare disease, clinically expressed in the form of numerous, dense, isolated nodules, from a pinhead to a lentil size, spherical, conical or flat shape, with pigmentation and lichenification. The disease is accompanied by itching of varying intensity. The course is chronic. Localization is the upper and, especially, lower extremities. Sometimes the regional lymph nodes swell. Amyloid degeneration of internal organs is not observed. The diagnosis is established by biopsy. Histologically: deposition of amyloid in the papillary layer and superficial layers of the dermis. The horny layer over the amyloid masses is thickened. The etiology is unclear.
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Cite this page
“Skin Amyloidosis.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/skin-amyloidosis/