Alypin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Alypin is a synthetic anesthetic derived from tertiary amyl alcohol, used as a less toxic alternative to cocaine for local anesthesia. It produces anesthesia within 2-3 minutes that lasts 15-20 minutes and can be administered through various routes including subcutaneous injection, spinal canal, and eye drops.
Encyclopedia article (1928–1936)
ALYPIN, Alypinum, a synthetic anesthetic agent, a derivative of tertiary amyl alcohol, tetramethyl-di-amidobenzoyl-pentanol: CII2.N(CH3)2 CH2.CO.O-C6H4-CH,N(CH3)2 C5H11. The hydrochloride salt of A. is a white crystalline powder, easily soluble in water; solutions of A. have a neutral reaction and are sterilized by boiling. A. is used for local anesthesia, as a substitute for the more toxic cocaine. Anesthesia from A. begins in 2-3 minutes and lasts 15-20 minutes. Upon absorption, A. may cause slowing of the heartbeat, weakening of respiration, slight dilation of blood vessels, but slightly increases blood pressure; it may cause convulsions. At the site of administration, A. does not cause ischemia; in the eye, A. does not affect the pupil, intraocular pressure, or accommodation. 2% solutions of A. are used in doses of 0.5-2 cubic cm, administered subcutaneously, into the spinal canal, and by drops into the eye; 1-4% solutions of A. are used in urological practice; 10-20% solutions of A. for smearing the nasal mucous membranes.
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Cite this page
“Alypin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/alypin/