Epiphysin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Epiphysin is the name given to a hypothetical substance contained in the pineal gland and possessing hormonal functions. It has not been isolated in pure form, but dried pineal gland from young animals is used as a treatment for children with growth retardation and in gynecology for increased libido.
Encyclopedia entry (1928–1936)
Epiphysin, the name given to a hypothetical substance contained in the pineal gland and possessing hormonal functions. E. has not been obtained in isolated form. The preparation of preparations containing E. and their use was proposed by Berkeley in 1913. The preparations containing E. currently in use consist of dried fresh pineal gland from young animals. One part of dried gland corresponds on average to eight parts of fresh gland. Water extracts of the gland for subcutaneous injections are prepared in the same way. E. is recommended as a therapeutic agent in children with delayed growth. In gynecology, P. Werner recommended the use of E. in cases of increased libido. The dose of dried gland is 0.01-0.03 three times a day for many months with periodic intervals.
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Cite this page
“Epiphysin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/epiphysin/