Euphylline
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Euphylline is a compound of theophylline with ethylenediamine, used for its pharmacological effects similar to theophylline but with better absorption due to increased solubility. It is administered orally, intramuscularly, intravenously, and rectally for conditions such as angina pectoris, with potential side effects including nausea, vomiting, headache, diarrhea, and convulsions.
Encyclopedia entry (1928–1936)
EUPHYLLINE, Euphyllin, a compound of theophylline with ethylenediamine, C7H8N4O2-C2H4(NH2)2, molecular weight 240.2; a white powder, easily soluble in water. Its pharmacological action is the same as that of theophylline (theocin). Absorption occurs more rapidly due to better solubility. It is administered orally in doses of 0.1-0.2 three to four times a day; intramuscularly and intravenously in ampoules of 10 ml with 0.48 g of E. (to be administered slowly). E. is also often prescribed in suppositories in doses of 0.3-0.5 g. The indications are the same as for theophylline. Intravenously for angina pectoris. With careless use, it causes a number of side effects: nausea, vomiting, headache, diarrhea, and convulsions.
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“Euphylline.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/euphylline/