Eucupin

EUCUPIN, basic, Eucupinum basicum, a quinine derivative, chemically iso-amylhydrocupreine, C₁₉H₂₁NO₄; molecular weight 382.3; a colorless powder, odorless, almost tasteless; insoluble in water, easily soluble in alcohol, ether, chloroform, and essential and fatty oils. It has a strong bactericidal effect on various cocci and the diphtheria bacillus; it also has a local anesthetic effect. Rarely administered internally: 0.25-0.5 several times a day. Side effects: urinary tract disturbances, tinnitus, visual disturbances. Externally, E. is used as a local anesthetic in 1-3% oil solution for bladder anesthesia in tuberculosis, in 2-5% ointments for ulcerated carcinomas, in 2% suppositories for proctitis; as an antiseptic - in the treatment of diphtheria, for sterilizing diphtheria bacillus carriers, in Plaut-Vincent's angina, for injection into abscesses in 0.5-1% solution. E. hydrochloride dissolves in 15 parts water, easily in alcohol. Used in the same cases and in the same dosage as basic E. EUMENOL (eumenol), an extract from the root of tang-kui (tangui) (Angelica anomala chinensis, China); a brownish-yellow liquid, bitter-aromatic taste, acidic reaction. In Chinese medicine, the root of tang-kui is used as a menstrual remedy without abortifacient action. In experiments on dogs, E. causes a decrease in blood pressure, contraction of the uterus, bladder, and intestinal musculature. The active principle has not been determined. Given in tablets of 0.3-0.5 E., 2-4 tablets for amenorrhea, mainly of neurogenic origin.