Gottlieb

Gottlieb, Rudolf (Rudolf Gottlieb, 1864-1924), a renowned pharmacologist who held the chair at the University of Heidelberg from 1898. The most significant of G.'s research concerns the effects on the heart and blood vessels of depressing agents (chloral hydrate, diphtheria toxin) and stimulants (camphor, hexeton, digitalin, adrenaline, etc.). Questions regarding adrenaline-like substances formed in the blood serum during the breakdown of blood platelets, and the toxicity of blood during transfusion, were studied by G. and directly connected with the question of protein therapy. Problems of acquired immunity against plant toxins and chronic morphine poisoning were also developed by G. Experimentally, he demonstrated that substances of the antipyrine group act centrally, causing increased heat emission, while quinine lowers temperature by limiting metabolism and thereby reducing heat production. In addition, G. researched iron excretion, the pharmacology of picrotoxin, the physiology and pharmacology of the pancreas; the action of tropine and tropine; the structure of methylxanthine, which is excreted after the administration of caffeine and theobromine; the local anesthetic action of psicain and many other topics. Together with Professor Meyer (H. Meyer), G. published the well-known to physicians and specialists exemplary textbook of experimental pharmacology - "Experimentelle Pharmakologie als Grundlage der Arzneibehandlung" (Berlin-Vienna, 7 editions, 1910-25), translated into Russian (St. Petersburg, 1913). To a large extent thanks to the works of G., clinicians and practical physicians in their daily work began not only to take into account the data of experimental pharmacology, but also closely intertwined clinical research with the solution of pharmacological problems.