Istizin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Istizin (1,8-dihydroxyanthraquinone) is a synthetic orange crystalline powder used as a laxative in 1930s medicine. It stimulates large intestine peristalsis, taking effect 8 to 16 hours after administration, and can cause harmless discoloration of the urine.
Encyclopedia entry (1928–1936)
ISTIZIN (Istizin), C14H8O4, 1,8-dihydroxyanthraquinone, is produced synthetically from anthraquinone. It is an orange crystalline powder, odorless and tasteless, melting at 190-192°; it is sparingly soluble in water. Istizin enhances the peristalsis of the large intestine and consequently has a laxative effect, which appears 8-16 hours after ingestion. The urine is colored dark yellow, or blood-red in strongly acidic urine. Side effects are occasionally noted: intestinal colic and urticaria. The dose is 0.1-0.5 per dose, 1-2 times a day.
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“Istizin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/istizin/