Trypanrot

TRYANROT, trypanrot, a water-soluble and lipid-insoluble red dye, which in its chemical structure and physicochemical properties is very close to Trypan blue (see).

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II SHIN, Na0₃S S0₃Na H_aN/VS S0₃Na

NaO_sS KjsJ S0₃Na In aqueous solutions it is colloidal and diffuses very poorly; as a rule, it does not pass through animal membranes. The biological properties of this dye have been studied less than those of trypan blue. When introduced into the organism, it is not deposited in cells in the form of granularity; it disappears from the blood according to the same patterns as trypan blue (Bilttner), and can be used to determine the total amount of blood in the body (Seyderhelm u. Lampe). Trypanrot was introduced into medicine in 1906. It was used without noticeable success orally and subcutaneously in stomach cancer and inflammations of the lymph glands. Dose: 0.5 is dissolved in 40 cm³ of lukewarm water (35°) and injected into the thigh. For trypanosomiasis diseases, it was used by Ehrlich and Shiga; at present, for these diseases, it has been replaced by other preparations. For experimental work, it is also used, like Trypan blue. Lit.-see lit. to the article Trypan blue.