Fibrolysin

FIBROLYSIN (Fibrolysinum), a double compound of one particle of thiosinamine, C₃H₄NHCSNH₂, with half a particle of sodium salicylate, or Thiosinaminum natriosalicylicum, a white crystalline powder, easily soluble in water; unstable; in the presence of air and light it oxidizes and decomposes; very rapidly broken down in the body: 10-15 seconds after intravenous injection the patient feels a garlic or mustard smell and taste. F. was introduced into medical practice for the more convenient use of thiosinamine properties. The latter is rapidly absorbed, locally causes irritation - hyperemia occurs, serous fluid exudes from vessels into the tissue, the tissue swells, leukolysis occurs followed by leukocytosis, whereby resorption is accelerated, scar tissue at the site of thiosinamine injection softens. This effect of the drug has been established in patients with lupus, in burn scars, in corneal opacity, in adhesions of the esophagus, serous membranes, etc.; favorable results from F. were also observed in such cases, as well as in chronic arthritis, parametrial scars, and urethral strictures. Subcutaneous injection of F. causes a burning sensation, while intramuscular injections are painless; with intravenous injections a thrombosis may form. F. is sold in sealed ampules, sterile. An ampule contains 2-3 cm³ of a 15% solution of F.; injections are given every 2-3 days. F. is also used in pastes. By adding ethyl iodide to thiosinamine, the compound iodoethyl-thiosinamine, thiophysem (Thiophysem or Tiodin), is obtained, a water-soluble powder containing 46.5% iodine; it is used in all cases where F. and thiosinamine are applied, additionally in tabes, in some tumors in the lungs, 0.05-0.1 three times a day in pills, in capsules or subcutaneously in 20% solutions.