Histogenic

HISTOGENIC, histogenic (from Greek histion-tissue and genesis-origin), originating from tissue. One speaks of histogenic immunity, i.e., tissue immunity, opposing it to humoral immunity (the theory of Ehrlich and others) on the one hand and to cellular immunity (the theory of phagocytosis by Metchnikoff) on the other. Savchenko was the first to point out that individual tissues of the organism can be immune to microorganisms. The doctrine of histogenic immunity was then developed by many authors and especially by A. M. Bezredka, who attempted to prove that 1) the susceptibility of animals to anthrax is limited to the cells of the skin and 2) that immunity in animals depends on the vaccination of sensitive cells. He strove to extend the same view in relation to other infections (staphylococcus, streptococcus, typhuses, dysentery) and other tissues (the mucous membrane of the intestinal tract). The question of tissue immunity has not yet received its resolution (literature see Immunity).-The histogenic origin of white blood elements is observed during inflammation. It is manifested in the multiplication and transformation of the endothelium of vessels, the reticular cells of adipose tissue, and reticulo-endothelial tissue in general. Thus, both granular leukocytes and lymphocytes and polymorphoblasts can be histogenically tissue-derived. The formation of mobile forms during inflammation is also possible from the tissue of neuroglia and peritoneal epithelium.