Lympho-Epithelial Formations

LYMPHO-EPITHELIAL FORMATIONS are observed in retroperitoneal glands, particularly along their sinuses, and less commonly in the neck glands. The origin of such formations is not entirely clear. Their frequency in ulcerative processes in the lymphatic origins, specifically in the corresponding mucous membranes [colitis, endometritis, in the so-called ranula of the sublingual area (Neumeister)], seems to support the theory of benign metastasis of epithelium into the glands and its subsequent vegetation. On the other hand, a unique metamorphosis of the sinus endothelium of the glands, which takes on cubic or cylindrical forms under the influence of chronic irritation, cannot be excluded. Finally, the so-called lympho-epithelial tumors, or lymphoepitheliomas (Schmincke, Jovin), should also be classified as lympho-epithelial formations. These are malignant neoplasms of the root of the tongue, palatine tonsils, nasopharyngeal area, larynx, and less commonly the thyroid gland. Such tumors differ little from carcinomas and sarcomas in their behavior, giving metastases to the neck area and later to internal organs, for example, the liver and bones. The histological characteristic of such lympho-epithelial tumors is the closest interweaving of typical or syncytial epithelial complexes with lymphocytes. Such tumors have been described in small numbers and mainly in young people. As a distinctive biological feature of these tumors, their extreme sensitivity to radiation is noted, which is the best method of treatment (P. Greet); however, there are also contrary conclusions (J. Ewing). The nature of such lymphoepitheliomas remains controversial. Schminke himself classifies them as bronchogenic carcinomas; others generally deny their independence and propose to consider such tumors as ordinary carcinomas with subsequent infiltration by lymphocytes (Dietrich, Marx).

I. Davydovsky