Thymophyzin

THYMOPHYZIN, a preparation representing a mixture of thyroid gland extract and pituitrin and prepared after N. Temesvary reported in 1925 that when thyroid gland extract is added to pituitrin, the spasmodic contractions of the uterus observed with pituitrin injection transform into rhythmic ones that correspond to normal labor contractions. Subsequently, it was found that the same effect can be obtained by replacing the thyroid gland extract with an extract from muscle tissue. At present, the preparation under the name T. ("myophyzin"), consisting of a mixture of pituitrin and extract from cattle muscles, is produced by the "Farmakon" factory in Leningrad. T. is packaged in boxes of 6 ampoules of 1.0 each. Its activity is determined by the pharmacopoeial method established for pituitrin, taking into account that T. contains only half the amount of pituitrin. T. is used in weak labor activity, using it from the very beginning of labor, as well as during the period of cervical dilation. T. does not have a harmful effect on the fetus. It is injected subcutaneously in doses of 0.5-1.0, usually twice with intervals of 45-60 minutes. The action of T. and its significance in therapy are being studied in clinics and experimental laboratories and are not yet firmly established.