Yatren

YATREN, Yatren (trien, xanthropon), a yellowish, odorless powder, soluble (with the release of CO₂) in hot water, insoluble in alcohol, ether, and other organic solvents. It contains 26–28% iodine. It is sold as a mixture of 80% 8-hydroxy-7-iodo-5-quinolinesulfonic acid with 20% sodium bicarbonate. The preparation possesses significant antiseptic properties: a 5% solution of Yatren kills anthrax spores after 3 hours, and a 0.01% solution kills gonococci within 2 hours. Yatren has no effect on normal tissue, does not act hemolytically on cells, and does not lower the phagocytic capacity of leukocytes; it induces the formation of healthy granulations. Yatren, administered internally, subcutaneously, or intramuscularly, does not produce harmful effects at appropriate dosages. Yatren is not deposited in the organism and is excreted unchanged by the kidneys. Along with its significant bactericidal action, its ability to exhibit a stimulating resorptive action similar to the irritation phenomena upon introducing foreign protein (protein therapy) is utilized. Yatren is used in the treatment of diphtheria and angina via inhalations; in the form of 10–20% solutions for tampons of the uterus and vagina in female gonorrhea; for intravenous infusion of 0.25 of Yatren in a 5% aqueous solution for gonorrhea at 2-day intervals. For colitis, Yatren is given internally for 6–8 days at 0.25 three times a day; after an 8-day pause, Yatren is given 3 times a day at 0.25, combined with enemas of 1–2% Yatren solution at 100 cm³ once a day. For acute and chronic rheumatism (articular and muscular), intramuscular and subcutaneous injections of a 5% Yatren solution—5 cm³ every 1–2 days—are used. Yatren has acquired outstanding significance in the treatment of acute and chronic amoebic dysentery, as well as its bacillary form. In these diseases, Yatren is used internally and in enemas. Internally, adults are prescribed 0.5 up to 5 times a day or up to 1.0 up to 3 times a day. If severe diarrhea appears at the start of treatment, the dose should be reduced and then gradually increased to the indicated amount. For enemas, a 1–2% Yatren solution at 200 cm³ per single use is applied after a preliminary cleansing enema. The course of treatment is 6–10 days; if necessary, the course is repeated after a pause of 6–7 days. In wound treatment, Yatren replaces iodoform. A 4% Yatren solution with vaccines is used for treating strep, staph, and gonococcal diseases. Side effects from Yatren: some irritation and hyperemia in wound treatment, a feeling of pressure in the epigastric region when taken internally, and a rise in temperature upon intravenous infusion.

I. Zelikin.