Antithyreoidin
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Antithyreoidin is a serum from thyroidectomized animals (sheep, goats, dogs) proposed in 1895 by Ballet and Enriquez, and later by Moebius, for treating Basedow's disease. The treatment was based on the theory that this serum could neutralize excess thyroid hormone in the blood of patients with hyperthyroidism.
Encyclopedia article (1928–1936)
ANTITHYREOIDIN, Antithyreoidin, serum of thyroidectomized animals (sheep, goats, dogs), proposed (1895) for the treatment of Basedow's disease by Ballet and Enriquez, and later also by Moebius. These authors based the advisability of using the serum of animals with removed thyroid gland in Basedow's disease on the idea that the excess of thyroid hormone existing in the blood in hyperthyroidism can be neutralized by introducing into the organism the serum of thyroidectomized animals. Due to the absence of thyroid hormone in such serum, special substances are formed that neutralize the excess of thyroid hormone in the blood of Basedow patients and thereby reduce the pathological phenomena. The following preparations, produced in the USSR, are used: "Antithyreoidin" (in tablets and liquid form) - Ukrainian San.-Bact. Institute (Kharkov) and "Antithyreocrin" (liquid and powder) of the Institute of Experimental Endocrinology of the People's Commissariat of Health (Moscow) - 1 tablet or 20-30 drops 2-3 times a day; subcutaneously - 5 cubic cm every 1-2 days. Among foreign preparations, A. Merck (Merck, Germany) in tablet and drop form is widely used.
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“Antithyreoidin.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/antithyreoidin/