Brissaud Disease

Brissaud Disease (Brissaud), infantilism associated with insufficient activity of the thyroid gland. The disease was described by Brissaud in 1897 and named by him "infantilisme myxoedemateux", or "infantilisme dysthyroidien". The condition is characterized by infantile body proportions, atrophy of the thyroid gland, and myxedematous swelling of the skin. The ratio of head size to body size is much greater than normal; the skeleton is poorly developed, with a short, thick neck, delayed ossification of epiphyseal cartilage, delayed or absent tooth replacement; a round, puffy, hairless face; sparse eyebrows and eyelashes; subcutaneous tissue is strongly developed everywhere, masking the contours of bones and muscles; no hair on the pubis and under the arms; a childish voice; the thyroid gland is atrophied; the sexual organs are often rudimentary; mental development is significantly reduced. Possible therapy - preparations of the thyroid gland.