Dihydrocodeinone

DIHYDROCODEINONE, Dicodid, Dihydrocodeinon, is obtained from codeine by oxidizing it into codeinone and adding two hydrogen atoms. In its effects, it occupies an intermediate position between morphine and codeine; it is particularly noted for its depressing effect of D. on the respiratory center and cerebral cortex. Therefore, it is used for cough and as an analgesic (for example, in diseases of the urinary tract); at the same time, it reduces the excitability of the sexual sphere (F. Simon); in gynecology, in the post-operative period and in other cases where opium preparations are indicated, D. does not cause constipation. Addiction to it is less compared to morphine. Preparations of D.: hydrochloride of D. (D. hydrochloricum) for subcutaneous injection in 0.015 doses in ampoules; for internal use - bitartrate of D. (D. bitartricum) in 0.005 to 0.015 doses in tablets. Side effects: nausea, headache, urticaria.