Tutocaine

Tutocaine, Tutocain, the hydrochloride salt of p-amino-benzoyl-alpha-dimethyl-amino-beta-methyl-gamma-butanol; a synthetic drug, structurally similar to novocaine (CH₃ ^XCfCH₃ \CHU.N.(CH₃)₂HCl. A white crystalline powder, soluble in water. Unlike cocaine, it is stable when boiled and provides well-preserved, sterilizable solutions. Its anesthetic power is almost equal to and even exceeds that of cocaine and is 8 times more active than novocaine. It hardly irritates tissues. The duration of anesthesia is 2-3 times longer than that of novocaine, but after anesthesia, soreness of the operative field is observed. In terms of toxicity, it is twice that of novocaine. According to clinical reviews, tutocaine combines the qualities of both cocaine and novocaine. It is applicable for all types of anesthesia in combination with adrenaline. Solutions of T. are prepared in 0.6-0.8% NaCl solutions. For regional anesthesia, a 0.5% solution of T. is used; 0.25% for infiltration anesthesia; 5-10% for anesthesia of mucous membranes, except for the urinary tract (1%) and eye (2%); for spinal anesthesia, 1.5% solutions are used; in dentistry-0.5-1%; for anesthesia of the p. splanchnici, a 74% solution is recommended. Anesthesia sets in quickly and lasts 3-5 hours. The highest dose is 0.3. Despite its low toxicity, cases of poisoning have been observed, especially with surface anesthesia, in the form of nausea, vomiting, fainting, cyanosis, shortness of breath, convulsions, and collapse.