Blood Coagulability
Historical document, translated for reference. It reflects medical knowledge of the 1920s–30s and is not medical advice.
Summary
Blood coagulability refers to the ability of blood to overcome the influence of substances that delay its clotting. This concept, introduced by the Bernese surgeon Fonio, is measured by the concentration of magnesium sulfate at which blood still forms a clot.
Encyclopedia article (1928–1936)
BLOOD COAGULABILITY, the ability of blood to overcome the influence of substances that delay its clotting (for example, magnesium sulfate). The concept was introduced by the Bernese surgeon Fonio. The basis of the special method for determining blood coagulability, proposed by this author and suitable for clinical use, is the determination of the concentration of MgSO4 at which blood still forms a "blood clot." For normal values, this concentration, denoted by V, ranges from 1.5-2.5% MgSO4. Figures above and below this are considered pathological by Fonio. In hemophilia, "blood coagulability" is sharply reduced: a blood clot does not form even in distilled water; atrophic cirrhosis of the liver also gives low figures (V=0.5% MgSO4). In myxedema, blood coagulability, on the contrary, is sharply increased. Verification of Fonio's method based on material from over 100 studies of various diseases of the blood-forming organs in the clinical-hematological department of the Blood Transfusion Institute (Moscow) confirmed its significance.
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“Blood Coagulability.” Soviet Medical Encyclopedia. English translation of Bolshaya Meditsinskaya Entsiklopediya, 1st ed. (Moscow, 1928–1936), ed. N. A. Semashko. https://sovietmedicalencyclopedia.pages.dev/article/blood-coagulability/