Nateina

NATEINA, Nateina, a preparation proposed in 1925 by Lopis; represents a mixture of vitamins A, B, C, D, of plant origin with calcium phosphate and milk sugar. The exact quantitative composition is unknown. The preparation is patented. The first reports on the clinical use of N. were made by Spanish clinics, and at the end of 1927 and the beginning of 1928, information appears about the successful use of nateina in Soviet clinics in the treatment of hemophilia. Dosage: from 6 to 40 tablets per day. First intake on an empty stomach. Tablets need to be chewed. In most cases, treatment is prolonged for many months with the possibility of only temporary reduction in dosage, but not complete cessation of taking the preparation. Breaks in treatment of N. in severe cases are accompanied by deterioration. The mechanism of action of N. is unclear. Under the influence of long-term use of N., severe, especially fatal, bleeding is eliminated. Bleeding and effusions in the joints recur much less frequently after the medication and, when they appear, resolve relatively quickly. Patients recover well, their work capacity¹ increases. Minor injuries and lesions are tolerated by hemophiliacs as by normal people. Minor operations become possible for hemophiliacs. Often the calcium content in the blood, blood coagulability, also increases. Moreover, during the treatment of N., red blood cells and blood protein remain at the upper limit of normal. However, it should be noted that even a significant increase in blood coagulability is often not accompanied by improvement in the clinical picture, and conversely, N. was successfully used in the treatment of pellagra and noted a decrease in blood calcium content to normal. By comparing the effect of N. on blood calcium in hemophilia (increase to normal) and in pellagra, Prados and Such (Prados and Such) conclude that this circumstance emphasizes the importance of vitamins in restoring the lost balance of ions¹. Harmful effects of N. have not yet been noted by any of the authors. However, according to Morawitz (Morawitz), the preparation is insufficiently theoretically substantiated and may be indifferent to the body, considering the enormous vitamin content.