Hematogenous

HEMATOGENOUS (from Greek haima-blood and genesis-origin), blood-derived, originating from blood or otherwise related to blood. The disease of an organ by hematogenous pathway means the transmission of the pathogenic cause through the blood. Thus, among the etiological factors causing heart diseases (along with mechanical, hemodynamic, nervous, and other causes), hematogenous factors also play a role, for example, when the heart is involved in the process by circulating exogenous or endogenous blood toxins or when particles causing embolism of coronary vessels are transmitted through the blood. The hematogenous pathway has significant importance in the dissemination of the pathogenic agent throughout the body and underlies the transformation of a purely local condition into a general one (generalization of diseases). It is precisely by this pathway that what is known as bacteremia, sepsis, and metastases arise. Hematogenous immunity is immunity due to the presence of protective antibodies in the blood, in contrast to histogenous immunity, in which the essence of the phenomenon is reduced to the peculiarities not of the blood but of the tissues themselves. At one time, the term "hematogenous glycosuria" was also used, which referred to cases where glycosuria is a consequence of hyperglycemia, in contrast to nephrogenic glycosuria, caused by increased permeability of the renal filter for sugar. However, since glycosurias of the latter type are extremely rare (floridzin glycosuria), this term, although correct in essence, has fallen out of use.